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In addition, another study reported an early infiltration of neutrophils into regions of the brain that influence feeding behavior and/or energy metabolism, such as the hypothalamus, which contributes to anorexia and muscle atrophy in a mouse model of pancreatic ductal adenocarcinoma ( According to macrophages, it has been reported that in adipose tissue they contribute to the regulation of fat loss in a model of hepatocellular carcinoma (HCC)-associated cachexia ( + macrophage muscle infiltration correlates with skeletal muscles atrophy in patients with pancreatic cancer and macrophage depletion leads to reduced systemic inflammation and muscle wasting in pancreatic tumor-bearing mice, indicating that both macrophage number and polarization might play a role in the progression of cancer cachexia (Shukla et al., 2020)